Variant selection to maximize variance explained in cis-Mendelian randomization

Summary: Optimal selection of instrumental variables (IVs) from a single gene region in cis-Mendelian randomization (MR) is challenging, as variants are highly correlated due to linkage disequilibrium (LD). Using only the lead variant is convenient but may not achieve full statistical power if multi...

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Autors principals:	Ang Zhou, Ville Karhunen, Haodong Tian, Janne Pott, Ashish Patel, Eric A.W. Slob, Stephen Burgess
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-04-01
Col·lecció:	HGG Advances
Matèries:	cis-Mendelian randomization cis-MR variant selection variance explained drug target Mendelian randomization linkage disequilibrium
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666247726000138
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