Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

ABSTRACT The incidence of osteoarthritis (OA) is strongly correlated with aging. It has been shown that the accumulation of senescent cells in the synovium precedes chondrocyte senescence and cartilage degradation, suggesting that synovial cell senescence plays a key role in OA pathogenesis. This st...

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Detalhes bibliográficos

Principais autores:	Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-03-01
Colecção:	Advanced Science
Assuntos:	chondrocytes macrophages osteoarthritis synovial fibroblasts
Acesso em linha:	https://doi.org/10.1002/advs.202518056
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