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27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression: A key target potentially linking zearalenone and cancer

Zearalenone (ZEN) is a mycotoxin that extensively contaminates food and feed, posing a significant threat to public health. However, the mechanisms behind ZEN-induced intestinal immunotoxicity remain unclear. In this study, Sprague-Dawley (SD) rats were exposed to ZEN at a dosage of 5 mg/kg/day b.w....

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Principais autores: Haonan Ruan, Jing Zhang, Yunyun Wang, Ying Huang, Jiashuo Wu, Chunjiao He, Tongwei Ke, Jiaoyang Luo, Meihua Yang
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-03-01
Series:Journal of Pharmaceutical Analysis
Assuntos:
Zearalenone
Intestinal immunosuppression
Apolipoprotein E
Bioinformatics analysis
Cancer
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2095177923001880
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