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Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis.

The heparan sulfate proteoglycan 2 (HSPG2)/perlecan gene is ancient and conserved in all triploblastic species. Its presence maintains critical cell boundaries in tissue and its large (up to ~900 kDa) modular structure has prompted speculation about the evolutionary origin of the gene. The gene's co...

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Principais autores: Curtis R Warren, Elias Kassir, James Spurlin, Jerahme Martinez, Nicholas H Putnam, Mary C Farach-Carson
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC4398486?pdf=render
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