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Cycloastragenol Attenuates Osteoclastogenesis and Bone Loss by Targeting RANKL-Induced Nrf2/Keap1/ARE, NF-κB, Calcium, and NFATc1 Pathways

Osteoporosis, which typically affects postmenopausal women, is an osteolytic disease due to over-activation of osteoclasts. However, current drugs targeting osteoclast inhibition face various side effects, making natural compounds with great interest as alternative treatment options. Cycloastragenol...

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Principais autores: Gang Wang, Chao Ma, Kai Chen, Ziyi Wang, Heng Qiu, Delong Chen, Jianbo He, Cheng Zhang, Ding Guo, Boyong Lai, Shuangxiao Zhang, Linfeng Huang, Fan Yang, Jinbo Yuan, Leilei Chen, Wei He, Jiake Xu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-01-01
Serier:Frontiers in Pharmacology
Fag:
cycloastragenol
osteoclast
RANKL
Nfatc1
ROS
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.810322/full
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