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Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

IntroductionGenetic polymorphisms in CYP2D6 and CYP2C19 significantly influence the metabolism, efficacy, and safety of antidepressant medications. Limited data exist on the prevalence of these actionable pharmacogenetic variants in the Central Indian population. This study aimed to determine the fr...

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Principais autores: Santenna Chenchula, Atal Shubham, Rozatkar Abhijit, Tamonud Modak, Kohat Komal, Ratinder Jhaj, Singh Jitendra, Satyaprakash V., Sadasivam Balakrishnan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-11-01
Serier:Frontiers in Pharmacology
Fag:
pharmacogenetics
CYP2D6
CYP2C19
antidepressants
common mental disorders
indian population
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1697866/full
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