Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy

Abstract Non-small cell lung cancer (NSCLC) constitutes one of the deadliest and most common malignancies. The LKB1/STK11 tumour suppressor is mutated in ∼ 30% of NSCLCs, typically lung adenocarcinomas (LUAD). We implemented zebrafish and human lung organoids as synergistic platforms to pre-clinical...

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Ngā kaituhi matua:	Andriani Angelopoulou, Giorgos Theocharous, Dimitrios Valakos, Aikaterini Polyzou, Sophia Magkouta, Vassilios Myrianthopoulos, Sophia Havaki, Marco Fiorillo, Ioanna Tremi, Konstantinos Vachlas, Theodoros Nisotakis, Dimitris-Foivos Thanos, Anastasia Pantazaki, Dimitris Kletsas, Jiri Bartek, Russell Petty, Dimitris Thanos, Rory J McCrimmon, Angelos Papaspyropoulos, Vassilis G Gorgoulis
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2024-07-01
Rangatū:	Molecular Cancer
Ngā marau:	Non-small cell lung cancer (NSCLC) LKB1/STK11 HIF1A-LEP-UCP2 axis Zebrafish Metabolic stress Piceatannol
Urunga tuihono:	https://doi.org/10.1186/s12943-024-02061-4
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