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Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy

Abstract Non-small cell lung cancer (NSCLC) constitutes one of the deadliest and most common malignancies. The LKB1/STK11 tumour suppressor is mutated in ∼ 30% of NSCLCs, typically lung adenocarcinomas (LUAD). We implemented zebrafish and human lung organoids as synergistic platforms to pre-clinical...

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Wedi'i Gadw mewn:
Prif Awduron: Andriani Angelopoulou, Giorgos Theocharous, Dimitrios Valakos, Aikaterini Polyzou, Sophia Magkouta, Vassilios Myrianthopoulos, Sophia Havaki, Marco Fiorillo, Ioanna Tremi, Konstantinos Vachlas, Theodoros Nisotakis, Dimitris-Foivos Thanos, Anastasia Pantazaki, Dimitris Kletsas, Jiri Bartek, Russell Petty, Dimitris Thanos, Rory J McCrimmon, Angelos Papaspyropoulos, Vassilis G Gorgoulis
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2024-07-01
Cyfres:Molecular Cancer
Pynciau:
Non-small cell lung cancer (NSCLC)
LKB1/STK11
HIF1A-LEP-UCP2 axis
Zebrafish
Metabolic stress
Piceatannol
Mynediad Ar-lein:https://doi.org/10.1186/s12943-024-02061-4
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