Third-trimester estradiol is associated with isolated maternal hypothyroxinemia and attenuated TSH–FT4 coupling: evidence from rats and human astrocytes

IntroductionIsolated maternal hypothyroxinemia (IMH), defined by low free thyroxine (FT4) with thyroid-stimulating hormone (TSH) within the reference range, is a clinically relevant thyroid phenotype in late pregnancy, when estradiol (E2) rises sharply. We tested whether third-trimester E2 is associ...

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Hauptverfasser:	Yajing Xu, Zitong Wang, Qingyan Cai, Honghong Duan, Huibin Huang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-04-01
Schriftenreihe:	Frontiers in Endocrinology
Schlagworte:	DIO2 estradiol isolated maternal hypothyroxinemia OATP1C1 pituitary pregnancy
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1795855/full
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