Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

Abstract Background After myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial dysfunction. Direct reprogramming of fibroblasts into cardiomyocytes via the forced overexpression of cardiac transcription factors Gata4, Mef2c, and Tb...

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Autori principali:	Juntao Fang, Qiangbing Yang, Renée G. C. Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-01-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Vitamin C Cardiac reprogramming ROS Cardiac regeneration
Accesso online:	https://doi.org/10.1186/s13287-023-03615-x
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