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Extracellular vesicle‐mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin‐kexin type 9 (Pcsk9) in primary mouse hepatocytes

Abstract The loss‐of‐function of the proprotein convertase subtilisin–kexin type 9 (Pcsk9) gene has been associated with significant reductions in plasma serum low‐density lipoprotein cholesterol (LDL‐C) levels. Both CRISPR/Cas9 and CRISPR‐based editor‐mediated Pcsk9 inactivation have successfully l...

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Uloženo v:
Hlavní autoři: Nazma F. Ilahibaks, Thomas A. Kluiver, Olivier G. deJong, Saskia C. A. deJager, Raymond M. Schiffelers, Pieter Vader, Weng Chuan Peng, Zhiyong Lei, Joost P. G. Sluijter
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley 2024-01-01
Edice:Journal of Extracellular Vesicles
Témata:
cholesterol‐lowering therapy
CRISPR/Cas9 delivery
exosomes
extracellular vesicles
gene therapy
increased LDL‐C uptake
On-line přístup:https://doi.org/10.1002/jev2.12389
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