Extracellular vesicle‐mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin‐kexin type 9 (Pcsk9) in primary mouse hepatocytes

Abstract The loss‐of‐function of the proprotein convertase subtilisin–kexin type 9 (Pcsk9) gene has been associated with significant reductions in plasma serum low‐density lipoprotein cholesterol (LDL‐C) levels. Both CRISPR/Cas9 and CRISPR‐based editor‐mediated Pcsk9 inactivation have successfully l...

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Автори:	Nazma F. Ilahibaks, Thomas A. Kluiver, Olivier G. deJong, Saskia C. A. deJager, Raymond M. Schiffelers, Pieter Vader, Weng Chuan Peng, Zhiyong Lei, Joost P. G. Sluijter
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Wiley 2024-01-01
Серія:	Journal of Extracellular Vesicles
Предмети:	cholesterol‐lowering therapy CRISPR/Cas9 delivery exosomes extracellular vesicles gene therapy increased LDL‐C uptake
Онлайн доступ:	https://doi.org/10.1002/jev2.12389
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