RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular Osteoradionecrosis—study protocol for an open-label phase II randomised controlled superiority trial

Abstract Background Mandibular osteoradionecrosis (ORN) is a severe late radiation toxicity affecting 5–10% of patients who receive radiotherapy as part of treatment for head and neck malignancy. ORN can cause permanent disfigurement, dysfunction, pain and infection. There remains little robust evid...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Richard Shaw, Ruth Knight, Ayten Basoglu, Mandeep Bajwa, Julie Perry, Anastasios Kanatas, Stefano Fedele, Vincent Killen, Rebecca Tangney, Chris Butterworth, James McCaul, Jagtar Dhanda, Vinod Patel, Mererid Evans, Richard Jackson
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-07-01
Цуврал:	Trials
Нөхцлүүд:	Mandible Osteoradionecrosis Radiotherapy Head and neck Cancer PENTOCLO
Онлайн хандалт:	https://doi.org/10.1186/s13063-025-08966-9
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!