RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular Osteoradionecrosis—study protocol for an open-label phase II randomised controlled superiority trial

Abstract Background Mandibular osteoradionecrosis (ORN) is a severe late radiation toxicity affecting 5–10% of patients who receive radiotherapy as part of treatment for head and neck malignancy. ORN can cause permanent disfigurement, dysfunction, pain and infection. There remains little robust evid...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Richard Shaw, Ruth Knight, Ayten Basoglu, Mandeep Bajwa, Julie Perry, Anastasios Kanatas, Stefano Fedele, Vincent Killen, Rebecca Tangney, Chris Butterworth, James McCaul, Jagtar Dhanda, Vinod Patel, Mererid Evans, Richard Jackson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-07-01
Serie:	Trials
Soggetti:	Mandible Osteoradionecrosis Radiotherapy Head and neck Cancer PENTOCLO
Accesso online:	https://doi.org/10.1186/s13063-025-08966-9
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!