Loss of mechanical stress induces synovitis, fibrosis and articular cartilage degeneration via distinct synovial cell subsets

Abstract Joint function is impaired by disuse, as well as overuse. However, the underlying mechanisms remain unclear. Here, we elucidate the mechanisms of synovial and cartilage changes using a minimized mechanical stress (MMS) mouse model by combining knee joint immobilization and unloading. In thi...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Hisatoshi Ishikura, Hiroyuki Okada, Yota Kin, Ryota Chijimatsu, Junya Higuchi, Junya Miyahara, Naohiro Tachibana, Kosei Nagata, Asuka Terashima, Fumiko Yano, Yasunori Omata, Masahide Seki, Yutaka Suzuki, Roland Baron, Sakae Tanaka, Taku Saito
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2026-02-01
Rangatū:	Scientific Reports
Urunga tuihono:	https://doi.org/10.1038/s41598-026-39416-4
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!