Loss of mechanical stress induces synovitis, fibrosis and articular cartilage degeneration via distinct synovial cell subsets

Abstract Joint function is impaired by disuse, as well as overuse. However, the underlying mechanisms remain unclear. Here, we elucidate the mechanisms of synovial and cartilage changes using a minimized mechanical stress (MMS) mouse model by combining knee joint immobilization and unloading. In thi...

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Bibliografische gegevens

Hoofdauteurs:	Hisatoshi Ishikura, Hiroyuki Okada, Yota Kin, Ryota Chijimatsu, Junya Higuchi, Junya Miyahara, Naohiro Tachibana, Kosei Nagata, Asuka Terashima, Fumiko Yano, Yasunori Omata, Masahide Seki, Yutaka Suzuki, Roland Baron, Sakae Tanaka, Taku Saito
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Nature Portfolio 2026-02-01
Reeks:	Scientific Reports
Online toegang:	https://doi.org/10.1038/s41598-026-39416-4
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