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d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged following entry of these antibiotics via the mechano-electrical...

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Autors principals: Nerissa K. Kirkwood, Molly O'Reilly, Marco Derudas, Emma J. Kenyon, Rosemary Huckvale, Sietse M. van Netten, Simon E. Ward, Guy P. Richardson, Corné J. Kros
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017-09-01
Col·lecció:Frontiers in Cellular Neuroscience
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Accés en línia:http://journal.frontiersin.org/article/10.3389/fncel.2017.00262/full
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