Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

To identify small molecules that shield mammalian sensory hair cells from the ototoxic side effects of aminoglycoside antibiotics, 10,240 compounds were initially screened in zebrafish larvae, selecting for those that protected lateral-line hair cells against neomycin and gentamicin. When the 64 hit...

Description complète

Détails bibliographiques

Auteurs principaux:	Emma J. Kenyon, Nerissa K. Kirkwood, Siân R. Kitcher, Richard J. Goodyear, Marco Derudas, Daire M. Cantillon, Sarah Baxendale, Antonio de la Vega de León, Virginia N. Mahieu, Richard T. Osgood, Charlotte Donald Wilson, James C. Bull, Simon J. Waddell, Tanya T. Whitfield, Simon E. Ward, Corné J. Kros, Guy P. Richardson
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical investigation 2021-04-01
Collection:	JCI Insight
Sujets:	Neuroscience Therapeutics
Accès en ligne:	https://doi.org/10.1172/jci.insight.145704
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!