Evaluation of CDK9 Inhibition by Dinaciclib in Combination with Apoptosis Modulating izTRAIL for the Treatment of Colorectal Cancer

Treatment options for colorectal cancer (CRC), especially in advanced stages are still insufficient. There, the discovery of Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) was a bright spot. However, most cancers show resistance toward apoptotic signals. Cyclin-dependent kinas...

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Autori principali:	Xiao Shen, Anna-Laura Kretz, Sandra Schneider, Uwe Knippschild, Doris Henne-Bruns, Marko Kornmann, Johannes Lemke, Benno Traub
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-03-01
Serie:	Biomedicines
Soggetti:	TNF-related apoptosis-inducing ligand (TRAIL) cyclin-dependent kinases (CDKs) CDK9 dinaciclib colorectal cancer (CRC) drug target
Accesso online:	https://www.mdpi.com/2227-9059/11/3/928
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