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Tissue tropism and functional adaptation of the SARS-CoV-2 spike protein in a fatal case of COVID-19

ABSTRACT Systemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to extrapulmonary tissues has been observed following acute infections. Autopsy studies further indicate tissue-specific virus diversity, including in immune-privileged sites. Questions remain on the viral dynam...

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Автори: Katherine E. E. Johnson, Sydney Stein, Rita Afriyie Boateng, Shilpi Jain, Sabrina C. Ramelli, Trevor Stantliff, Shelly Curran, Marcos J. Ramos-Benítez, Andrew P. Platt, Stephanie Banakis, Wei Wang, Stephen M. Hewitt, Christa Zerbe, Steven M. Holland, Elizabeth M. Kang, Manmeet Singh, Emmie de Wit, William A. Lauer, Eric C. Rouchka, Melissa Smith, Mehul S. Suthar, Daniel S. Chertow, Elodie Ghedin
Формат: Artigo
Мова:Inglês
Опубліковано: American Society for Microbiology 2025-11-01
Серія:Journal of Virology
Предмети:
viral evolution
viral intrahost diversity
tissue tropism
coronavirus
Онлайн доступ:https://journals.asm.org/doi/10.1128/jvi.00857-25
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