PLC-γ-Ca2+ pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling

Brain-derived neurotrophic factor (BDNF) and its tropomyosin receptor kinase B (TrkB) are important signaling proteins that regulate dendritic growth and maintenance in the central nervous system (CNS). After binding of BDNF, TrkB is endocytosed into endosomes and continues signaling within the cell...

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Autors principals:	Guillermo Moya-Alvarado, Xavier Valero-Peña, Alejandro Aguirre-Soto, Fernando J. Bustos, Oscar M. Lazo, Francisca C. Bronfman
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2024-04-01
Col·lecció:	Frontiers in Molecular Neuroscience
Matèries:	PLC-γ brain-derived neurotrophic factor TrkB axonal transport signaling endosomes dendritic branching
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnmol.2024.1009404/full
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