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PLC-γ-Ca2+ pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling

Brain-derived neurotrophic factor (BDNF) and its tropomyosin receptor kinase B (TrkB) are important signaling proteins that regulate dendritic growth and maintenance in the central nervous system (CNS). After binding of BDNF, TrkB is endocytosed into endosomes and continues signaling within the cell...

Täydet tiedot

Tallennettuna:
Päätekijät: Guillermo Moya-Alvarado, Xavier Valero-Peña, Alejandro Aguirre-Soto, Fernando J. Bustos, Oscar M. Lazo, Francisca C. Bronfman
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2024-04-01
Sarja:Frontiers in Molecular Neuroscience
Aiheet:
PLC-γ
brain-derived neurotrophic factor
TrkB
axonal transport
signaling endosomes
dendritic branching
Linkit:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1009404/full
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