Microbial lung-to-blood translocation associates with systemic inflammation in severe pneumonia: evidence from paired plasma and lower respiratory tract metagenomics

Abstract Background Biological heterogeneity in host inflammatory responses to severe pneumonia predicts clinical outcomes and may influence the effectiveness of immunomodulatory therapy. The upstream drivers of this heterogeneity remain poorly defined. We hypothesized that microbial translocation f...

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Detalhes bibliográficos

Principais autores:	Haopu Yang, Matthew K. Hensley, Vi D.-B. Nguyen, Nameer S. Al-Yousif, Noel Britton, Ghady Haidar, Libing Yang, Faraaz Shah, William Bain, Xiaohong Wang, Shulin Qin, Asim A. Ahmed, Tim Blauwkamp, Sivan Bercovici, Brett A. Kaufman, Kevin M. Redding, Adam Fitch, Barbara Methé, Panayiotis V. Benos, Bryan J. McVerry, Alison Morris, Georgios D. Kitsios
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2026-02-01
coleção:	Intensive Care Medicine Experimental
Assuntos:	Severe pneumonia Metagenomics Host–microbe interaction
Acesso em linha:	https://doi.org/10.1186/s40635-026-00862-z
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