Microbial lung-to-blood translocation associates with systemic inflammation in severe pneumonia: evidence from paired plasma and lower respiratory tract metagenomics

Abstract Background Biological heterogeneity in host inflammatory responses to severe pneumonia predicts clinical outcomes and may influence the effectiveness of immunomodulatory therapy. The upstream drivers of this heterogeneity remain poorly defined. We hypothesized that microbial translocation f...

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मुख्य लेखकों:	Haopu Yang, Matthew K. Hensley, Vi D.-B. Nguyen, Nameer S. Al-Yousif, Noel Britton, Ghady Haidar, Libing Yang, Faraaz Shah, William Bain, Xiaohong Wang, Shulin Qin, Asim A. Ahmed, Tim Blauwkamp, Sivan Bercovici, Brett A. Kaufman, Kevin M. Redding, Adam Fitch, Barbara Methé, Panayiotis V. Benos, Bryan J. McVerry, Alison Morris, Georgios D. Kitsios
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	SpringerOpen 2026-02-01
श्रृंखला:	Intensive Care Medicine Experimental
विषय:	Severe pneumonia Metagenomics Host–microbe interaction
ऑनलाइन पहुंच:	https://doi.org/10.1186/s40635-026-00862-z
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