Cód QR

A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy

Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of cancer treatment, yet the lack of predictive human models continues to hinder therapeutic progress. Here, we establish a scalable and reproducible model of paclitaxel-induced axon degeneration and neur...

Cur síos iomlán

Sábháilte in:
Príomhchruthaitheoirí: Veselina Petrova, Caitlin E. Mills, Clemens Hug, Aysel Cetinkaya-Fisgin, Jennifer Splaine, Sepideh Fouladzadeh, Sara Hakim, Rasheen Powell, Shannon Zhen, Mirra Chung, Gary A. Bradshaw, Tao Deng, Ilyas Singec, Qing Wang, Riki Kawaguchi, Harathi Jonnagaddala, Lee B. Barrett, Jennifer A. Smith, Marian Kalocsay, Benjamin M. Gyori, Ahmet Hoke, Peter K. Sorger, Clifford J. Woolf
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2026-05-01
Sraith:Cell Reports Medicine
Ábhair:
chemotherapy-induced peripheral neuropathy
iPSC-derived sensory neurons
high-throughput screening
neuroprotective small molecules
axon degeneration
STE20 kinases
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2666379126002041
Clibeanna: Cuir clib leis
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

Míreanna comhchosúla