A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy

Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of cancer treatment, yet the lack of predictive human models continues to hinder therapeutic progress. Here, we establish a scalable and reproducible model of paclitaxel-induced axon degeneration and neur...

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Main Authors:	Veselina Petrova, Caitlin E. Mills, Clemens Hug, Aysel Cetinkaya-Fisgin, Jennifer Splaine, Sepideh Fouladzadeh, Sara Hakim, Rasheen Powell, Shannon Zhen, Mirra Chung, Gary A. Bradshaw, Tao Deng, Ilyas Singec, Qing Wang, Riki Kawaguchi, Harathi Jonnagaddala, Lee B. Barrett, Jennifer A. Smith, Marian Kalocsay, Benjamin M. Gyori, Ahmet Hoke, Peter K. Sorger, Clifford J. Woolf
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2026-05-01
Series:	Cell Reports Medicine
Subjects:	chemotherapy-induced peripheral neuropathy iPSC-derived sensory neurons high-throughput screening neuroprotective small molecules axon degeneration STE20 kinases
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666379126002041
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