Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma

IntroductionIntra-tumoral heterogeneity is a prominent characteristic of hepatocellular carcinoma (HCC). However, it remains unexplored whether intra-tumoral transcriptomic differences can capture crucial information regarding HCC evolution and be utilized to derive a predictive signature for patien...

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Hauptverfasser: Shangyi Luo, Li Liu, Yang Sun, Jian Shi, Yajing Zhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-08-01
Schriftenreihe:Frontiers in Bioinformatics
Schlagworte:
hepatocellular carcinoma
multi-region sequencing
expression dynamics
tumor evolution
prognostication
Online Zugang:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1669236/full
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