The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using multi-regional sampling of nine resected HCC with different aetiologies, here we construct phylogenetic relationships of these sectors, showing diverse levels of genetic sharing, spanning early to late diversif...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhai, Weiwei, Lim, Tony Kiat-Hon, Zhang, Tong, Phang, Su-Ting, Tiang, Zenia, Guan, Peiyong, Ng, Ming-Hwee, Lim, Jia Qi, Yao, Fei, Li, Zheng, Ng, Poh Yong, Yan, Jie, Goh, Brian K., Chung, Alexander Yaw-Fui, Choo, Su-Pin, Khor, Chiea Chuen, Soon, Wendy Wei-Jia, Sung, Ken Wing-Kin, Foo, Roger Sik-Yin, Chow, Pierce Kah-Hoe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333358/
https://ncbi.nlm.nih.gov/pubmed/28240289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14565
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