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Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation

Hepatocellular carcinoma (HCC) is disease with a high mortality rate and limited treatment options. Alterations of fibroblast growth factor receptor 4 (FGFR4) has been regarded as an oncogenic driver for HCC and a promising target for HCC therapeutics. Herein, we report that GNF-7, a multi-targeted...

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Principais autores: Yunju Nam, Injae Shin, Younghoon Kim, SeongShick Ryu, Namdoo Kim, Eunhye Ju, Taebo Sim
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-01-01
coleção:Neoplasia: An International Journal for Oncology Research
Assuntos:
FGFR4 kinase
HCC
FGFR4 inhibitor
GNF-7
SAR
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1476558621001019
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