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A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs results in disease. An analysis of RasGRP1 SNP variants led to the conclusion that the charge of His 212 in RasGRP1 alters...

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Principais autores: Yvonne Vercoulen, Yasushi Kondo, Jeffrey S Iwig, Axel B Janssen, Katharine A White, Mojtaba Amini, Diane L Barber, John Kuriyan, Jeroen P Roose
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2017-09-01
coleção:eLife
Assuntos:
small GTPases
RasGRP
Signaling
Structure
Lymphocytes
RasGEFs
Acesso em linha:https://elifesciences.org/articles/29002
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