Janus Kinase Inhibitor Treatment Results in Rapid but Incomplete Immune Reconstitution and Resolution of Monocyte-Driven Hyperinflammation in STAT1 Gain-of-Function

Autosomal-dominant STAT1 gain-of-function (GOF) is an inborn error of immunity characterized by chronic mucocutaneous candidiasis and variable autoimmune manifestations. Janus kinase (JAK) inhibitors are a promising treatment, but their efficacy remains variable and incompletely understood. We evalu...

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Hlavní autoři:	Cecilia Iglesias Herrero, Willem Roosens, Georgina Galicia, Jonathan Cremer, Nam Joo van der Veken, Timothy Devos, Leen Moens, Isabelle Meyts, Rik Gijsbers, Rik Schrijvers
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Rockefeller University Press 2026-05-01
Edice:	Journal of Human Immunity
On-line přístup:	https://rupress.org/jhi/article/2/CIS2026/eCIS2026abstract.76/282028/Janus-Kinase-Inhibitor-Treatment-Results-in-Rapid
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