Janus Kinase Inhibitor Treatment Results in Rapid but Incomplete Immune Reconstitution and Resolution of Monocyte-Driven Hyperinflammation in STAT1 Gain-of-Function

Autosomal-dominant STAT1 gain-of-function (GOF) is an inborn error of immunity characterized by chronic mucocutaneous candidiasis and variable autoimmune manifestations. Janus kinase (JAK) inhibitors are a promising treatment, but their efficacy remains variable and incompletely understood. We evalu...

Descrición completa

Detalles Bibliográficos

Principais autores:	Cecilia Iglesias Herrero, Willem Roosens, Georgina Galicia, Jonathan Cremer, Nam Joo van der Veken, Timothy Devos, Leen Moens, Isabelle Meyts, Rik Gijsbers, Rik Schrijvers
Formato:	Artigo
Idioma:	Inglês
Publicado:	Rockefeller University Press 2026-05-01
Series:	Journal of Human Immunity
Acceso en liña:	https://rupress.org/jhi/article/2/CIS2026/eCIS2026abstract.76/282028/Janus-Kinase-Inhibitor-Treatment-Results-in-Rapid
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!