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Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

Abstract Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson’s disease (PD), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (SN) and striatum (STR) regions. However, the underlying...

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Principais autores: Pingping Song, Shanshan Li, Hao Wu, Ruize Gao, Guanhua Rao, Dongmei Wang, Ziheng Chen, Biao Ma, Hongxia Wang, Nan Sui, Haiteng Deng, Zhuohua Zhang, Tieshan Tang, Zheng Tan, Zehan Han, Tieyuan Lu, Yushan Zhu, Quan Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016-01-01
coleção:Protein & Cell
Assuntos:
parkin
sequestosome1/p62
ubiquitin
substantia nigra
Acesso em linha:http://link.springer.com/article/10.1007/s13238-015-0230-9
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