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STAT1 drives the immune landscape of murine Toll-like receptor 9-induced liver inflammation

Background & Aims: Persistent activation of Toll-like receptor 9 (TLR9) has been implicated in eliciting a cytokine storm syndrome, leading to systemic and hepatic inflammation in mice and humans. This study investigates the unexplored role of STAT1, a transcription factor in pathogen-driven imm...

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Hoofdauteurs: Amber De Visscher, Jarne Beliën, Eline Bernaerts, Marte Vandeput, Bert Malengier-Devlies, Fran Prenen, Hanne Meers, Liliana Sokol, Tania Mitera, Nele Berghmans, Seray Anak, Olivier Govaere, Philippe Van den Steen, Jochen Lamote, Niels Vandamme, Anna Bujko, Charlotte L. Scott, Carine H. Wouters, Patrick Matthys
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2026-02-01
Reeks:JHEP Reports
Onderwerpen:
CpG-induced liver inflammation
IFN-α/β
IFN-γ
scRNA-seq
MAS
PSC
Online toegang:http://www.sciencedirect.com/science/article/pii/S2589555925003519
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