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DRP1 depletion protects NK cells from hypoxia-induced dysfunction

Objectives The efficacy of cellular therapies has been disappointing in solid tumors. A major barrier that contributes to the low success rate, is hypoxia within the tumor microenvironment. In this study, we investigated the influence of hypoxia on natural killer (NK) cell function and to evaluated...

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Главные авторы: Tias Verhezen, Astrid Van Den Eynde, Peter Verstraelen, Laura Gehrcken, Gabriele Palmiotto, Ho Wa Lau, Winnok H. De Vos, Sanne Van Der Heijden, Louize Brants, Jöran Melis, Jonas Van Audenaerde, Felicia Rodrigues Fortes, Maxim Le Compte, Geert Roeyen, Hans Prenen, Diana Campillo-Davo, Eva Lion, Rafael J. Argüello, Steven Van Laere, Filip Lardon, Christophe Deben, An Wouters, Evelien Smits, Jorrit De Waele
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis Group 2026-12-01
Серии:Redox Report
Предметы:
Natural killer cells
Tumor microenvironment
Hypoxia
Mitochondria
CRISPR-Cas9
ROS
Online-ссылка:https://www.tandfonline.com/doi/10.1080/13510002.2026.2626181
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