Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
Abstract Background Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leading to poor performance in populations of non-European ancestry. Results...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2022-01-01
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| coleção: | Genome Biology |
| Acesso em linha: | https://doi.org/10.1186/s13059-021-02591-w |
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