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The Combination of R848 with Sorafenib Enhances Antitumor Effects by Reprogramming the Tumor Immune Microenvironment and Facilitating Vascular Normalization in Hepatocellular Carcinoma

Abstract Novel promising strategies for combination with sorafenib are urgently needed to enhance its clinical benefit and overcome toxicity in hepatocellular carcinoma (HCC). the molecular and immunomodulatory antitumor effects of sorafenib alone and in combination with the new immunotherapeutic ag...

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Autori principali: Yuchao He, Linlin Zhan, Jian Shi, Manyu Xiao, Ran Zuo, Chengmeng Wang, Zhiyong Liu, Wenchen Gong, Liwei Chen, Yi Luo, Shaojun Zhang, Youwei Wang, Lu Chen, Hua Guo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2023-06-01
Serie:Advanced Science
Soggetti:
hepatocellular carcinoma
immune microenvironment
R848
sorafenib
vascular normalization
Accesso online:https://doi.org/10.1002/advs.202207650
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