HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways

High mobility group nucleosome-binding protein 1 (HMGN1 or N1) is a Th1-polarizing alarmin, but alone is insufficient to induce antitumor immunity. We previously showed that combination of N1 and R848, a synthetic TLR7/8 agonist, synergistically activates dendritic cells (DCs) and induces therapeuti...

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Principais autores:	Md Masud Alam, De Yang, Anna Trivett, Thomas J. Meyer, Joost J. Oppenheim
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2018-12-01
叢編:	Frontiers in Immunology
主題:	TLR HMGN1 R848 IFN NF-κB MAPK
在線閱讀:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02982/full
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