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Low-grade, systemic inflammation and the risk of perioperative neurocognitive disorders in an observational study of older adults

Abstract Aims The neuroinflammatory response to surgery may contribute to the pathogenesis of post-operative delirium (POD) and cognitive dysfunction (POCD), but whether inflammation before surgery enhances the risk of developing these conditions is unclear. Here, we investigate the relationship bet...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Insa Feinkohl, Daniel Hadzidiakos, Thomas B. Dschietzig, Jürgen Janke, Maria Heinrich, Arjen J.C. Slooter, Claudia Spies, Georg Winterer, Tobias Pischon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-12-01
Schriftenreihe:Scientific Reports
Schlagworte:
Ageing
Inflammation
Neuroepidemiology
Postoperative delirium
Postoperative cognitive dysfunction
Online-Zugang:https://doi.org/10.1038/s41598-025-31986-z
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