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Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing

Abstract Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a strategy using nanopore-based single-molecule sequencing to measure cfDNA methylomes. This approach generated up to 200 million reads for a s...

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Principais autores: Billy T. Lau, Alison Almeda, Marie Schauer, Madeline McNamara, Xiangqi Bai, Qingxi Meng, Mira Partha, Susan M. Grimes, HoJoon Lee, Gregory M. Heestand, Hanlee P. Ji
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-05-01
Serier:Genome Medicine
Fag:
Methylation
Single-molecule sequencing
Nanopore
Cell-free DNA
Online adgang:https://doi.org/10.1186/s13073-023-01178-3
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