Protocol for a multicentric open-label randomized controlled trial comparing low-dose (0.25 mg/kg) and standard-dose (0.75 mg/kg) primaquine for gametocytocidal efficacy and safety in Plasmodium falciparum malaria

Abstract Introduction World Health Organization (WHO) in 2010, recommended 0.75 mg/kg single dose primaquine for killing gametocytes after ruling out glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, considering the practical feasibility of G6PD testing, WHO revised the recommendation in...

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Principais autores:	Payal Gulati, Richa Singhal, Apoorv Gupta, Anjali, Praveen Kumar Tripathi, Dewesh Kumar, Diamond Prakash Sinha, S. P. Singh, Khileshwar Singh, Rajendra Kumar Baharia, K. N. Bhatt, Ashvin H. Vasava, Amit Gamit, Manoj B. Patki, Waseem A. Malla, Lokesh Kori, Deepali Savargaonkar, Nibir Chakma, Daksh Parmar, Lenin Alagesan, Ritika Kashyap, Kuldeep Singh, Anup R. Anvikar, Praveen K. Bharti, Nitika Nitika
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-05-01
Series:	Malaria Journal
Assuntos:	Primaquine Gametocyte clearance Plasmodium falciparum Efficacy Safety India
Acceso en liña:	https://doi.org/10.1186/s12936-026-05912-1
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