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Finding spatially variable ligand-receptor interactions with functional support from downstream genes

Abstract Spatial transcriptomics has emerged as a groundbreaking tool for the study of intercellular ligand-receptor interactions (LRIs) that exhibit spatial variability. To identify spatially variable LRIs with activation evidence, we present SPIDER, which constructs cell-cell interaction interface...

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Autors principals: Shiying Li, Ruohan Wang, Sitong Liu, Shuai Cheng Li
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2025-08-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-025-62988-0
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