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Engineering LNPs with polysarcosine lipids for mRNA delivery

Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-2 virus, there has been an increased interest in the delivery of mRNA through LNPs. However, current LNP formulations contain PEG lipids, which can stimulate the generation of anti-PEG antibodies. The presence of...

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Príomhchruthaitheoirí: Diana D. Kang, Xucheng Hou, Leiming Wang, Yonger Xue, Haoyuan Li, Yichen Zhong, Siyu Wang, Binbin Deng, David W. McComb, Yizhou Dong
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: KeAi Communications Co., Ltd. 2024-07-01
Sraith:Bioactive Materials
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Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2452199X24000987
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