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Radiotherapy-activated NBTXR3 nanoparticles promote ferroptosis through induction of lysosomal membrane permeabilization

Abstract Purpose Radiotherapy-activated NBTXR3 (NBTXR3 + RT) has demonstrated superior efficacy in cancer cell destruction and tumor growth control, compared to radiotherapy (RT), in preclinical and clinical settings. Previous studies highlighted the immunomodulatory properties of NBTXR3 + RT, such...

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Principais autores: Jordan Da Silva, Célia Bienassis, Peter Schmitt, Céline Berjaud, Mickael Guedj, Sébastien Paris
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-01-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Radiotherapy
Ferroptosis
Lipid peroxidation
Lysosome membrane permeabilization
Nanoparticle
NBTXR3
Acesso em linha:https://doi.org/10.1186/s13046-023-02938-0
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