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PARK7-driven IGF2BP3–K76 lactylation mediates ferroptosis and HAIC resistance in hepatocellular carcinoma

Oxaliplatin/5-fluorouracil (OXA/5-FU)-based hepatic artery infusion chemotherapy (HAIC) represents a promising strategy against advanced hepatocellular carcinoma (HCC), yet acquired resistance frequently impedes its efficacy. Here, we identify lactylation of IGF2BP3 at lysine 76 (IGF2BP3–K76lac) as...

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Principais autores: Zhiwen Zhu, Xinyu Xia, Yuanxiang Lu, Danfeng Li, Xincheng He, Baohua Zhang, Ge Xiong, Wanguang Zhang, Huifang Liang, Hong Zhu
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2025-11-01
סדרה:Redox Biology
נושאים:
IGF2BP3
Lactylation
PARK7
Ferroptosis
Chemoresistance
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2213231725003829
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