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Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cance...

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Principais autores: Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-08-01
Serier:Cancer Communications
Fag:
Chemo‐immunotherapy
Ferroptosis
Intrahepatic cholangiocarcinoma
Lactylation
Mevalonate pathway
PCK1
Online adgang:https://doi.org/10.1002/cac2.70036
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