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A porcine reproductive and respiratory syndrome virus (PRRSV)-specific IgM as a novel adjuvant for an inactivated PRRSV vaccine improves protection efficiency and enhances cell-mediated immunity against heterologous PRRSV challenge

Abstract Current strategies for porcine reproductive and respiratory syndrome (PRRS) control are inadequate and mainly restricted to immunization using different PRRS virus (PPRSV) vaccines. Although there are no safety concerns, the poor performance of inactivated PRRSV vaccines has restricted thei...

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Autori principali: Rui Chen, Bing Liu, Xiangmei Zhang, Mengmeng Qin, Jianhui Dong, Guoqian Gu, Chunyan Wu, Jingyu Wang, Yuchen Nan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2022-08-01
Serie:Veterinary Research
Soggetti:
PRRSV
inactivated PRRSV vaccine
broadly neutralizing antibody
monoclonal antibody
IgM
vaccine adjuvant
Accesso online:https://doi.org/10.1186/s13567-022-01082-5
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