Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome

Metabolic syndrome (MetS) is associated with osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and accumulation of arterial calcifications (ACs). Metformin (MET) inhibits this transdifferentiation in vitro. Here, we evaluate the in vivo efficacy of oral MET to reduce AC in a mo...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Bioscientifica 2025-01-01
Σειρά:	Endocrine Connections
Θέματα:	fructose metabolic syndrome metformin vascular smooth muscle cells osteogenic transdifferentiation advanced glycation end-products receptor for advanced glycation end-products
Διαθέσιμο Online:	https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0714.xml
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