Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome

Metabolic syndrome (MetS) is associated with osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and accumulation of arterial calcifications (ACs). Metformin (MET) inhibits this transdifferentiation in vitro. Here, we evaluate the in vivo efficacy of oral MET to reduce AC in a mo...

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Autori principali:	Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Bioscientifica 2025-01-01
Serie:	Endocrine Connections
Soggetti:	fructose metabolic syndrome metformin vascular smooth muscle cells osteogenic transdifferentiation advanced glycation end-products receptor for advanced glycation end-products
Accesso online:	https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0714.xml
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