Strain specific properties of Escherichia coli can prevent non-canonical amino acid misincorporation caused by scale-related process heterogeneities

Abstract Background Escherichia coli is one of the most important hosts for production of recombinant proteins in biopharmaceutical industry. However, when selecting a suitable production strain, it is often not considered that a lot of different sub-species exist, which can differ in their genotype...

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Hlavní autoři:	Florian Mayer, Monika Cserjan-Puschmann, Benedikt Haslinger, Anton Shpylovyi, Thomas Dalik, Christian Sam, Rainer Hahn, Gerald Striedner
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-08-01
Edice:	Microbial Cell Factories
Témata:	Scale-down Recombinant protein production Fab Norleucine misincorporation Escherichia coli
On-line přístup:	https://doi.org/10.1186/s12934-022-01895-1
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